IS THERE A ROLE FOR BRADYKININ IN CEREBRAL MALARIA PATHOGENESIS?

Is there a role for bradykinin in cerebral malaria pathogenesis?

Malaria is a parasitic disease of global health significance and a leading cause of death in children living in endemic regions.Although various Plasmodium species are responsible for the disease, Plasmodium falciparum infection accounts for most severe cases of the disease in humans.The mechanisms of cerebral malaria pathogenesis have been studied

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ETV6/RUNX1 Fusion Gene Abrogation Decreases the Oncogenicity of Tumour Cells in a Preclinical Model of Acute Lymphoblastic Leukaemia

Background: The t(12;21)(p13;q22), which fuses ETV6 and RUNX1 genes, is the most common genetic abnormality in children with B-cell precursor acute lymphoblastic leukaemia.The implication of the fusion protein in leukemogenesis seems to be clear.However, its role in the maintenance of the disease continues to be controversial.Methods: Generation of

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BIO-SECURE BUBBLE AMID COVID-19 PANDEMIC: PESTEL ANALYSIS

Physical distancing was recommended to break the chain of transmission, with 761402,282 confirmed cases worldwide.The Bio-secure bubble system consisted of routine COVID-19 testing and cleaning of tournament locations.PESTEL analysis is a technique for examining external macro-environmental variables that have an impact on a company Hair Spray or s

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Ecosystem service research in protected areas: A systematic review of the literature on current practices and future prospects

Protected areas (PAs) are globally important environmental management tools against the effects of human activities, as they support the conservation of marine biodiversity, habitats, ecosystems and the processes within them, as well as resources in a broad sense.However, the application of Ecosystem Services (ESs) research in the environmental man

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TRIB2 safeguards naive T cell homeostasis during aging

Summary: Naive CD4+ T cells are more resistant to age-related loss than naive CD8+ T cells, suggesting mechanisms that preferentially protect naive CD4+ T cells during aging.Here, we show that TRIB2 is more abundant in naive CD4+ than CD8+ T cells and counteracts quiescence exit by suppressing AKT activation.TRIB2 deficiency increases AKT activity

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